Towards the endgame and beyond: complexities and challenges for the elimination of infectious diseases
Identifieur interne : 001A13 ( Main/Exploration ); précédent : 001A12; suivant : 001A14Towards the endgame and beyond: complexities and challenges for the elimination of infectious diseases
Auteurs : Petra Klepac [Royaume-Uni] ; C. Jessica E. Metcalf [Royaume-Uni] ; Angela R. Mclean [Royaume-Uni] ; Katie Hampson [Royaume-Uni]Source :
- Philosophical Transactions of the Royal Society B [ 0962-8436 ] ; 2013.
Abstract
Successful control measures have interrupted the local transmission of human infectious diseases such as measles, malaria and polio, and saved and improved billions of lives. Similarly, control efforts have massively reduced the incidence of many infectious diseases of animals, such as rabies and rinderpest, with positive benefits for human health and livelihoods across the globe. However, disease elimination has proven an elusive goal, with only one human and one animal pathogen globally eradicated. As elimination targets expand to regional and even global levels, hurdles may emerge within the endgame when infections are circulating at very low levels, turning the last mile of these public health marathons into the longest mile. In this theme issue, we bring together recurring challenges that emerge as we move towards elimination, highlighting the unanticipated consequences of particular ecologies and pathologies of infection, and approaches to their management.
Url:
DOI: 10.1098/rstb.2012.0137
Affiliations:
- Royaume-Uni
- Angleterre, Angleterre de l'Est, Oxfordshire, Écosse
- Cambridge, Glasgow, Oxford
- Université d'Oxford, Université de Cambridge, Université de Glasgow
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Jessica E. Metcalf and Katie Hampson</title><title level="j" type="abbrev">Phil. Trans. R. Soc. B</title><idno type="ISSN">0962-8436</idno><idno type="eISSN">1471-2970</idno><imprint><publisher>The Royal Society</publisher><date type="published">2013</date><biblScope unit="vol">368</biblScope><biblScope unit="issue">1623</biblScope></imprint><idno type="ISSN">0962-8436</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0962-8436</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Successful control measures have interrupted the local transmission of human infectious diseases such as measles, malaria and polio, and saved and improved billions of lives. Similarly, control efforts have massively reduced the incidence of many infectious diseases of animals, such as rabies and rinderpest, with positive benefits for human health and livelihoods across the globe. However, disease elimination has proven an elusive goal, with only one human and one animal pathogen globally eradicated. As elimination targets expand to regional and even global levels, hurdles may emerge within the endgame when infections are circulating at very low levels, turning the last mile of these public health marathons into the longest mile. 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